I look at ways that different medicines can damage mitochondria in cells. This is one way that some medicines can cause toxic side-effects, such as reduced heart function or liver damage. Mitochondria are essential for making most of the energy a cell needs to survive and work properly. Organs that require a lot of energy to function (e.g. the brain, liver and heart) are particularly sensitive to mitochondrial damage by medicines. If I can help to understand how different medicines damage mitochondria, we can use this knowledge to help chemists design safer ones in the future.
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