• Question: what have you learn from your reseach

    Asked by dean123 to David on 4 Jun 2019.
    • Photo: David Wilson

      David Wilson answered on 4 Jun 2019:

      I’m hopefully about to publish some work that describes what happens when the tubes in your Liver, called bile ducts, become damaged and how they start to repair themselves.
      I found that macrophages, which are a cell involved in your immune system, send chemical signals to the cells that form the tube and tell them to start making scar tissue, also known as fibrotic tissue. Scar tissue sounds like a bad thing and it can be if you end up with too much of it or it forms out of control but actually it’s an essential part of repair and acts like the scaffold you’d see around a building getting built. It keeps the organs shape while other cells and structures grow.
      Understanding this signalling system is really helpful as it means we can think about how to fix it if it doesn’t work properly or even how to make it work better than it already does.